From Hell is a 2001 mystery horror thriller film directed by the Hughes Brothers and written by Terry Hayes and Rafael Yglesias. It is loosely based on the graphic novel From Hell by Alan Moore and Eddie Campbell about the Jack the Ripper murders. The film stars Johnny Depp as Frederick Abberline, the lead investigator of the murders, and Heather Graham as Mary Kelly, a sex worker targeted by the Ripper. Other cast members include Ian Holm, Robbie Coltrane, Ian Richardson and Jason Flemyng. It was an international co-production between the United Kingdom, the United States and Czech Republic.